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haldol iv for delirium |
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haldol iv for delirium Manufacturer: Ortho-McNeil Prescribing Information
Haloperidol decanoate is almost insoluble in water (0.01 mg/mL), but is solublein most organic solvents haldol iv for delirium. Each mL of HALDOL Decanoate 50 for IM injection contains 50 mg haloperidol(present as haloperidol decanoate 70.52 mg) in a sesame oil vehicle, with 1.2%(w/v) benzyl alcohol as a preservative haldol iv for delirium. Each mL of HALDOL Decanoate 100 for IM injection contains 100 mg haloperidol(present as haloperidol decanoate 141.04 mg) in a sesame oil vehicle, with 1.2%(w/v) benzyl alcohol as a preservative haldol iv for delirium.
Administration of haloperidol decanoate in sesame oil results in slow and sustainedrelease of haloperidol haldol iv for delirium. The plasma concentrations of haloperidol gradually rise,reaching a peak at about 6 days after the injection, and falling thereafter,with an apparent half-life of about 3 weeks haldol iv for delirium. Steady state plasma concentrationsare achieved after the third or fourth dose haldol iv for delirium. The relationship between dose ofhaloperidol decanoate and plasma haloperidol concentration is roughly linearfor doses below 450 mg haldol iv for delirium. It should be noted, however, that the pharmacokineticsof haloperidol decanoate following intramuscular injections can be quite variablebetween subjects haldol iv for delirium.
HALDOL is contraindicated in severe toxic central nervous system depressionor comatose states from any cause and in individuals who are hypersensitiveto this drug or have Parkinson's disease haldol iv for delirium.
Both the risk of developing tardive dyskinesia and the likelihood that it willbecome irreversible are believed to increase as the duration of treatment andthe total cumulative dose of antipsychotic drugs administered to the patientincrease haldol iv for delirium. However, the syndrome can develop, although much less commonly, afterrelatively brief treatment periods at low doses haldol iv for delirium. There is no known treatment for established cases of tardive dyskinesia, althoughthe syndrome may remit, partially or completely, if antipsychotic treatmentis withdrawn haldol iv for delirium. Antipsychotic treatment, itself, however, may suppress (or partiallysuppress) the signs and symptoms of the syndrome and thereby may possibly maskthe underlying process haldol iv for delirium. The effect that symptomatic suppression has upon thelong-term course of the syndrome is unknown haldol iv for delirium. Given these considerations, antipsychotic drugs should be prescribed in a mannerthat is most likely to minimize the occurrence of tardive dyskinesia haldol iv for delirium. Chronicantipsychotic treatment should generally be reserved for patients who sufferfrom a chronic illness that 1) is known to respond to antipsychotic drugs, and2) for whom alternative, equally effective, but potentially less harmful treatmentsare not available or appropriate haldol iv for delirium. In patients who do require chronic treatment,the smallest dose and the shortest duration of treatment producing a satisfactoryclinical response should be sought haldol iv for delirium. The need for continued treatment shouldbe reassessed periodically haldol iv for delirium. If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics,drug discontinuation should be considered haldol iv for delirium. However, some patients may requiretreatment despite the presence of the syndrome haldol iv for delirium. (For further information aboutthe description of tardive dyskinesia and its clinical detection, please referto ADVERSE REACTIONS .) Neuroleptic Malignant Syndrome (NMS)-- A potentially fatal symptom complexsometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reportedin association with antipsychotic drugs haldol iv for delirium. Clinical manifestations of NMS arehyperpyrexia, muscle rigidity, altered mental status (including catatonic signs)and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia,diaphoresis, and cardiac dysrhythmias) haldol iv for delirium. Additional signs may include elevatedcreatine phosphokinase, myoglobinuria (rhabdomyolysis) and acute renal failure haldol iv for delirium. The diagnostic evaluation of patients with this syndrome is complicated haldol iv for delirium. Inarriving at a diagnosis, it is important to identify cases where the clinicalpresentation includes both serious medical illness (e.g., pneumonia, systemicinfection, etc.) and untreated or inadequately treated extrapyramidal signsand symptoms (EPS) haldol iv for delirium. Other important considerations in the differential diagnosisinclude central anticholinergic toxicity, heat stroke, drug fever and primarycentral nervous system (CNS) pathology haldol iv for delirium. The management of NMS should include 1) immediate discontinuation of antipsychoticdrugs and other drugs not essential to concurrent therapy, 2) intensive symptomatictreatment and medical monitoring, and 3) treatment of any concomitant seriousmedical problems for which specific treatments are available haldol iv for delirium. There is no generalagreement about specific pharmacological treatment regimens for uncomplicatedNMS haldol iv for delirium. If a patient requires antipsychotic drug treatment after recovery from NMS,the potential reintroduction of drug therapy should be carefully considered haldol iv for delirium. The patient should be carefully monitored, since recurrences of NMS have beenreported haldol iv for delirium. Hyperpyrexia and heat stroke, not associated with the above symptom complex,have also been reported with HALDOL haldol iv for delirium. General-- A number of cases of bronchopneumonia, some fatal, have followedthe use of antipsychotic drugs, including HALDOL (haloperidol) haldol iv for delirium. It has beenpostulated that lethargy and decreased sensation of thirst due to central inhibitionmay lead to dehydration, hemoconcentration and reduced pulmonary ventilation haldol iv for delirium. Therefore, if the above signs and symptoms appear, especially in the elderly,the physician should institute remedial therapy promptly haldol iv for delirium. Although not reported with HALDOL, decreased serum cholesterol and/or cutaneousand ocular changes have been reported in patients receiving chemically-relateddrugs haldol iv for delirium.
If concomitant antiparkinson medication is required, it may have to be continuedafter HALDOL Decanoate 50 or HALDOL Decanoate 100 is discontinued because ofthe prolonged action of haloperidol decanoate haldol iv for delirium. If both drugs are discontinuedsimultaneously, extrapyramidal symptoms may occur haldol iv for delirium. The physician should keepin mind the possible increase in intraocular pressure when anticholinergic drugs,including antiparkinson agents, are administered concomitantly with haloperidoldecanoate haldol iv for delirium. In patients with thyrotoxicosis who are also receiving antipsychotic medication,including haloperidol decanoate, severe neurotoxicity (rigidity, inability towalk or talk) may occur haldol iv for delirium. When HALDOL is used to control mania in bipolar disorders, there may be a rapidmood swing to depression haldol iv for delirium. Information for Patients The use of alcohol with this drug should be avoided due to possible additiveeffects and hypotension haldol iv for delirium. |
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| hhaldol iv for delirium haaldol iv for delirium halldol iv for delirium halddol iv for delirium haldool iv for delirium haldoll iv for delirium haldol iv for delirium haldol iiv for delirium haldol ivv for delirium haldol iv for delirium haldol iv ffor delirium haldol iv foor delirium haldol iv forr delirium haldol iv for delirium haldol iv for ddelirium haldol iv for deelirium haldol iv for dellirium haldol iv for deliirium haldol iv for delirrium haldol iv for deliriium haldol iv for deliriuum haldol iv for deliriumm aldol iv for delirium hldol iv for delirium hadol iv for delirium halol iv for delirium haldl iv for delirium haldo iv for delirium haldoliv for delirium haldol v for delirium haldol i for delirium haldol ivfor delirium haldol iv or delirium haldol iv fr delirium haldol iv fo delirium haldol iv fordelirium haldol iv for elirium haldol iv for dlirium haldol iv for deirium haldol iv for delrium haldol iv for deliium haldol iv for delirum haldol iv for delirim haldol iv for deliriu h aldol iv for delirium ha ldol iv for delirium hal dol iv for delirium hald ol iv for delirium haldo l iv for delirium haldol iv for delirium haldol iv for delirium haldol i v for delirium haldol iv for delirium haldol iv for delirium haldol iv f or delirium haldol iv fo r delirium haldol iv for delirium haldol iv for delirium haldol iv for d elirium haldol iv for de lirium haldol iv for del irium haldol iv for deli rium haldol iv for delir ium haldol iv for deliri um haldol iv for deliriu m haldol iv for delirium ahldol iv for delirium hladol iv for delirium hadlol iv for delirium halodl iv for delirium haldlo iv for delirium haldo liv for delirium haldoli v for delirium haldol vi for delirium haldol i vfor delirium haldol ivf or delirium haldol iv ofr delirium haldol iv fro delirium haldol iv fo rdelirium haldol iv ford elirium haldol iv for edlirium haldol iv for dleirium haldol iv for deilrium haldol iv for delriium haldol iv for deliirum haldol iv for deliruim haldol iv for delirimu ahaldol iv for delirium thehaldol iv for delirium haldol iv for delirium | |||
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Copyright 2005 D-S LTD. |
