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schizophrenia and loss of concentration and haldol |
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schizophrenia and loss of concentration and haldol Manufacturer: Ortho-McNeil Prescribing Information
Haloperidol decanoate is almost insoluble in water (0.01 mg/mL), but is solublein most organic solvents schizophrenia and loss of concentration and haldol. Each mL of HALDOL Decanoate 50 for IM injection contains 50 mg haloperidol(present as haloperidol decanoate 70.52 mg) in a sesame oil vehicle, with 1.2%(w/v) benzyl alcohol as a preservative schizophrenia and loss of concentration and haldol. Each mL of HALDOL Decanoate 100 for IM injection contains 100 mg haloperidol(present as haloperidol decanoate 141.04 mg) in a sesame oil vehicle, with 1.2%(w/v) benzyl alcohol as a preservative schizophrenia and loss of concentration and haldol.
Administration of haloperidol decanoate in sesame oil results in slow and sustainedrelease of haloperidol schizophrenia and loss of concentration and haldol. The plasma concentrations of haloperidol gradually rise,reaching a peak at about 6 days after the injection, and falling thereafter,with an apparent half-life of about 3 weeks schizophrenia and loss of concentration and haldol. Steady state plasma concentrationsare achieved after the third or fourth dose schizophrenia and loss of concentration and haldol. The relationship between dose ofhaloperidol decanoate and plasma haloperidol concentration is roughly linearfor doses below 450 mg schizophrenia and loss of concentration and haldol. It should be noted, however, that the pharmacokineticsof haloperidol decanoate following intramuscular injections can be quite variablebetween subjects schizophrenia and loss of concentration and haldol.
HALDOL is contraindicated in severe toxic central nervous system depressionor comatose states from any cause and in individuals who are hypersensitiveto this drug or have Parkinson's disease schizophrenia and loss of concentration and haldol.
Both the risk of developing tardive dyskinesia and the likelihood that it willbecome irreversible are believed to increase as the duration of treatment andthe total cumulative dose of antipsychotic drugs administered to the patientincrease schizophrenia and loss of concentration and haldol. However, the syndrome can develop, although much less commonly, afterrelatively brief treatment periods at low doses schizophrenia and loss of concentration and haldol. There is no known treatment for established cases of tardive dyskinesia, althoughthe syndrome may remit, partially or completely, if antipsychotic treatmentis withdrawn schizophrenia and loss of concentration and haldol. Antipsychotic treatment, itself, however, may suppress (or partiallysuppress) the signs and symptoms of the syndrome and thereby may possibly maskthe underlying process schizophrenia and loss of concentration and haldol. The effect that symptomatic suppression has upon thelong-term course of the syndrome is unknown schizophrenia and loss of concentration and haldol. Given these considerations, antipsychotic drugs should be prescribed in a mannerthat is most likely to minimize the occurrence of tardive dyskinesia schizophrenia and loss of concentration and haldol. Chronicantipsychotic treatment should generally be reserved for patients who sufferfrom a chronic illness that 1) is known to respond to antipsychotic drugs, and2) for whom alternative, equally effective, but potentially less harmful treatmentsare not available or appropriate schizophrenia and loss of concentration and haldol. In patients who do require chronic treatment,the smallest dose and the shortest duration of treatment producing a satisfactoryclinical response should be sought schizophrenia and loss of concentration and haldol. The need for continued treatment shouldbe reassessed periodically schizophrenia and loss of concentration and haldol. If signs and symptoms of tardive dyskinesia appear in a patient on antipsychotics,drug discontinuation should be considered schizophrenia and loss of concentration and haldol. However, some patients may requiretreatment despite the presence of the syndrome schizophrenia and loss of concentration and haldol. (For further information aboutthe description of tardive dyskinesia and its clinical detection, please referto ADVERSE REACTIONS .) Neuroleptic Malignant Syndrome (NMS)-- A potentially fatal symptom complexsometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reportedin association with antipsychotic drugs schizophrenia and loss of concentration and haldol. Clinical manifestations of NMS arehyperpyrexia, muscle rigidity, altered mental status (including catatonic signs)and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia,diaphoresis, and cardiac dysrhythmias) schizophrenia and loss of concentration and haldol. Additional signs may include elevatedcreatine phosphokinase, myoglobinuria (rhabdomyolysis) and acute renal failure schizophrenia and loss of concentration and haldol. The diagnostic evaluation of patients with this syndrome is complicated schizophrenia and loss of concentration and haldol. Inarriving at a diagnosis, it is important to identify cases where the clinicalpresentation includes both serious medical illness (e.g., pneumonia, systemicinfection, etc.) and untreated or inadequately treated extrapyramidal signsand symptoms (EPS) schizophrenia and loss of concentration and haldol. Other important considerations in the differential diagnosisinclude central anticholinergic toxicity, heat stroke, drug fever and primarycentral nervous system (CNS) pathology schizophrenia and loss of concentration and haldol. The management of NMS should include 1) immediate discontinuation of antipsychoticdrugs and other drugs not essential to concurrent therapy, 2) intensive symptomatictreatment and medical monitoring, and 3) treatment of any concomitant seriousmedical problems for which specific treatments are available schizophrenia and loss of concentration and haldol. There is no generalagreement about specific pharmacological treatment regimens for uncomplicatedNMS schizophrenia and loss of concentration and haldol. If a patient requires antipsychotic drug treatment after recovery from NMS,the potential reintroduction of drug therapy should be carefully considered schizophrenia and loss of concentration and haldol. The patient should be carefully monitored, since recurrences of NMS have beenreported schizophrenia and loss of concentration and haldol. Hyperpyrexia and heat stroke, not associated with the above symptom complex,have also been reported with HALDOL schizophrenia and loss of concentration and haldol. General-- A number of cases of bronchopneumonia, some fatal, have followedthe use of antipsychotic drugs, including HALDOL (haloperidol) schizophrenia and loss of concentration and haldol. It has beenpostulated that lethargy and decreased sensation of thirst due to central inhibitionmay lead to dehydration, hemoconcentration and reduced pulmonary ventilation schizophrenia and loss of concentration and haldol. Therefore, if the above signs and symptoms appear, especially in the elderly,the physician should institute remedial therapy promptly schizophrenia and loss of concentration and haldol. Although not reported with HALDOL, decreased serum cholesterol and/or cutaneousand ocular changes have been reported in patients receiving chemically-relateddrugs schizophrenia and loss of concentration and haldol.
If concomitant antiparkinson medication is required, it may have to be continuedafter HALDOL Decanoate 50 or HALDOL Decanoate 100 is discontinued because ofthe prolonged action of haloperidol decanoate schizophrenia and loss of concentration and haldol. If both drugs are discontinuedsimultaneously, extrapyramidal symptoms may occur schizophrenia and loss of concentration and haldol. The physician should keepin mind the possible increase in intraocular pressure when anticholinergic drugs,including antiparkinson agents, are administered concomitantly with haloperidoldecanoate schizophrenia and loss of concentration and haldol. In patients with thyrotoxicosis who are also receiving antipsychotic medication,including haloperidol decanoate, severe neurotoxicity (rigidity, inability towalk or talk) may occur schizophrenia and loss of concentration and haldol. When HALDOL is used to control mania in bipolar disorders, there may be a rapidmood swing to depression schizophrenia and loss of concentration and haldol. Information for Patients The use of alcohol with this drug should be avoided due to possible additiveeffects and hypotension schizophrenia and loss of concentration and haldol. |
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