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What is the most important information I should know about HCTZ (hydrochlorothiazide)and irbesartan?
• Do not take HCTZ and irbesartan if you are pregnant or planning a pregnancy lisinopril hctz side effects. When used during the second and third trimesters of pregnancy, irbesartan cancause injury and even death to the developing baby lisinopril hctz side effects. Notify your doctor immediatelyif you think you might be pregnant lisinopril hctz side effects.
• Use caution when driving, operating machinery, or performing other hazardousactivities lisinopril hctz side effects. HCTZ (hydrochlorothiazide) and irbesartan may cause dizziness ordrowsiness lisinopril hctz side effects. If you experience dizziness or drowsiness, avoid these activities lisinopril hctz side effects. Also use caution when rising from a sitting or lying position lisinopril hctz side effects.
• Stop taking HCTZ and irbesartan and contact your doctor if lightheadednessor fainting occurs lisinopril hctz side effects.
• Use alcohol cautiously lisinopril hctz side effects. Alcohol may increase the drowsiness and dizzinessthat may occur while you are taking an HCTZ and irbesartan lisinopril hctz side effects.
• Avoid prolonged exposure to sunlight lisinopril hctz side effects. HCTZ and irbesartan may increasethe sensitivity of your skin to sunlight lisinopril hctz side effects. Use a sunscreen and wear protectiveclothing when exposure to the sun is unavoidable lisinopril hctz side effects.


What are HCTZ and irbesartan?
• Irbesartan is an angiotensin II receptor inhibitor, also called angiotensinII receptor antagonist, and is used to treat hypertension (high blood pressure) lisinopril hctz side effects.
• HCTZ is a thiazide diuretic (water pill) lisinopril hctz side effects. It increases the amount ofwater and salt you lose in your urine and decreases edema (swelling or fluidretention) lisinopril hctz side effects.
• Together, HCTZ and irbesartan are used to reduce hypertension (high bloodpressure) lisinopril hctz side effects.
• HCTZ and irbesartan may also be used for purposes other than those listedin this medication guide lisinopril hctz side effects.


Who should not take HCTZ and irbesartan?
• Do not take HCTZ and irbesartan without first talking to your doctorif you have an allergy to sulfa-based drugs such as sulfa antibiotics lisinopril hctz side effects. You mayhave an allergic reaction to hydrochlorothiazide lisinopril hctz side effects.
• Before taking HCTZ and irbesartan, tell your doctor if you
· have diabetes;
· have gout;
· have a collagen vascular disease such as systemic lupus erythematosus;
· have pancreatitis;
· have kidney disease;
· have liver disease;
· have high levels of cholesterol or triglycerides in your blood;
· have high levels of potassium in your blood; or
· are taking potassium a supplement (e.g., K-Dur, Klor-Con, others),or a potassium-sparing diuretic such as amiloride (Midamor), triamterene (Dyrenium,Dyazide, Maxzide), or spironolactone (Aldactone) lisinopril hctz side effects.
• You may not be able to take HCTZ and irbesartan, or you may require adosage adjustment or special monitoring during treatment if you have any ofthe conditions listed above lisinopril hctz side effects.
• HCTZ and irbesartan is in the FDA pregnancy category D lisinopril hctz side effects. This means thatit is known to cause birth defects in an unborn baby lisinopril hctz side effects. When used during the secondand third trimesters of pregnancy, irbesartan can cause injury and even deathof the developing baby lisinopril hctz side effects. Do not take this medication if you are pregnant lisinopril hctz side effects.
• HCTZ passes into breast milk and may harm a nursing infant lisinopril hctz side effects. It is notknown whether irbesartan passes into breast milk lisinopril hctz side effects. Do not take this medicationwithout first talking to your doctor if you are breast-feeding a baby lisinopril hctz side effects.


How should I take HCTZ and irbesartan?
• Take HCTZ and irbesartan exactly as directed by your doctor lisinopril hctz side effects. If you donot understand these directions, ask your pharmacist, nurse, or doctor to explainthem to you lisinopril hctz side effects.
• Take each dose with a full glass of water lisinopril hctz side effects.
• HCTZ and irbesartan can be taken with or without food lisinopril hctz side effects.
• Stop taking HCTZ and irbesartan and contact your doctor if lightheadednessor fainting occurs lisinopril hctz side effects.
• Do not stop taking this medication without first talking to your doctor lisinopril hctz side effects. If you stop taking this medication suddenly, your condition could become worse lisinopril hctz side effects.
• Store HCTZ and irbesartan at room temperature away from moisture andheat lisinopril hctz side effects.


What happens if I miss a dose?
• Take the missed dose as soon as you remember lisinopril hctz side effects. However, if it is almosttime for your next dose, skip the missed dose and take only your next regularlyscheduled dose lisinopril hctz side effects. Do not take a double dose of this medication lisinopril hctz side effects.


What happens if I overdose?
• Seek emergency medical attention lisinopril hctz side effects.
• Symptoms of an overdose of HCTZ and irbesartan are not well known butmay include dizziness, weakness, fainting, fatigue, low blood pressure, andchanges in heart rate lisinopril hctz side effects.


What should I avoid while taking HCTZ and irbesartan?
• Use caution when driving, operating machinery, or performing other hazardousactivities lisinopril hctz side effects. HCTZ and irbesartan may cause dizziness or drowsiness lisinopril hctz side effects. If you experiencedizziness or drowsiness, avoid these activities lisinopril hctz side effects. Also, use caution when risingfrom a sitting or lying position lisinopril hctz side effects.
• Stop taking HCTZ and irbesartan and contact your doctor if lightheadednessor fainting occurs lisinopril hctz side effects.
• Use alcohol cautiously lisinopril hctz side effects. Alcohol may increase the drowsiness and dizzinessthat may occur while you are taking HCTZ and irbesartan lisinopril hctz side effects.
• Avoid a diet high in salt lisinopril hctz side effects. Too much salt may cause your body to retainwater lisinopril hctz side effects. Talk to your doctor before making changes in your diet lisinopril hctz side effects.
• Do not use salt substitutes or take potassium supplements without firsttalking to your doctor lisinopril hctz side effects. HCTZ and irbesartan can affect potassium levels in yourbody lisinopril hctz side effects.
• Avoid prolonged exposure to sunlight lisinopril hctz side effects. HCTZ and irbesartan may increasethe sensitivity of your skin to sunlight lisinopril hctz side effects. Use a sunscreen and wear protectiveclothing when exposure to the sun is unavoidable lisinopril hctz side effects.
• Avoid becoming overheated in hot weather lisinopril hctz side effects. It is easy to become dangerouslydehydrated while you are taking HCTZ and irbesartan lisinopril hctz side effects.


What are the possible side effects of HCTZ and irbesartan?
• If you experience any of the following serious side effects, stop takingthis medication and call your doctor immediately or seek emergency medical treatment:
· an allergic reaction (difficulty breathing; closing of your throat;swelling of your lips, tongue, or face; or hives);
· fast heartbeats;
· little or no urine;
· unusual fatigue, abnormal bleeding or bruising;
· yellow skin or eyes;
· confusion; or
· fainting lisinopril hctz side effects.
• Other, less serious side effects may be more likely to occur lisinopril hctz side effects. Continueto take the medication and talk to your doctor if you experience
· dizziness;
· nausea or upset stomach;
· diarrhea;
· headache;
· cough;
· muscle pain or cramps;
· rash; or
· anxiety or nervousness lisinopril hctz side effects.
• Side effects other than those listed here may also occur lisinopril hctz side effects. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome lisinopril hctz side effects.


What other drugs will affect HCTZ and irbesartan?
• Before taking HCTZ and irbesartan, tell your doctor if you are taking
· a potassium supplement such as K-Dur, Klor-Con, and others;
· a potassium-sparing diuretic (water pill) such as amiloride (Midamor),spironolactone (Aldactone), or triamterene (Dyrenium, Dyazide, Maxzide);
· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,Advil, Nuprin), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Cataflam,Voltaren), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro),naproxen (Naprosyn, Anaprox, Aleve), and others;
· an oral diabetes medication such as glipizide (Glucotrol), glyburide(Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase),or tolbutamide (Orinase);
· a steroid medicine such as prednisone (Orasone, Deltasone, others),methylprednisolone (Medrol), prednisolone (Pediapred, Prelone), and others;
· cholestyramine (Questran) or colestipol (Colestid);
· lithium (Lithobid, Eskalith, others); or
· digoxin (Lanoxin) lisinopril hctz side effects.
• You may require a dosage adjustment or special monitoring during treatmentif you are taking any of the medicines listed above lisinopril hctz side effects.
• Drugs other than those listed here may also interact with HCTZ and irbesartanor affect your condition lisinopril hctz side effects. Talk to your doctor and pharmacist before taking anyprescription or over-the-counter medicines lisinopril hctz side effects.


Where can I get more information?
• Your pharmacist has additional information about HCTZ and irbesartanwritten for health professionals that you may read lisinopril hctz side effects.


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