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history of humulin
insulin isophane and insulin regular (IN suh lin EYE sew fane and IN suh lin REHgue ler)

What is the most important information I should know about Humulin 70/30?
• Know the signs and symptoms of low blood sugar (hypoglycemia), whichinclude shaking; nausea; headache; drowsiness; weakness; dizziness; fast heartbeat;sweating; pale, cool skin; anxiety; and difficulty concentrating history of humulin. Carry a pieceof candy or glucose tablets with you to treat episodes of low blood sugar history of humulin.
• Follow any diet and exercise plan that you have developed with your doctoror nurse history of humulin. Changes in what you eat or how much you exercise can change the amountof insulin that you need to control your blood sugar levels history of humulin.
• Ask your doctor or nurse what to do if you are sick with a cold, flu,or fever history of humulin. These illnesses may change your insulin requirements history of humulin.
• Do not change the brand of insulin isophane and insulin regular or syringethat you are using without first talking to your doctor or pharmacist history of humulin. Somebrands of insulin isophane and insulin regular and syringes are interchangeable,while others are not history of humulin. Your doctor and/or pharmacist know which brands can besubstituted for one another history of humulin.


What is Humulin 70/30?
• Insulin is a hormone naturally produced by your pancreas history of humulin. Insulin enablesthe body to use the sugar in food as a source of energy history of humulin. When the body doesnot produce enough insulin, or when the insulin produced by the body is noteffective enough, the condition is called diabetes mellitus history of humulin. This conditionallows sugar levels in the blood to become very high history of humulin. Diabetics must use man-madeinsulin or insulin that comes from pigs (which is very similar to human insulin)to lower these high blood sugar levels history of humulin.
• Humulin 70/30 is used in the treatment of diabetes mellitus history of humulin.
• Humulin 70/30 may also be used for purposes other than those listed inthis medication guide history of humulin.


What should I discuss with my healthcare provider before using Humulin 70/30?
• Do not use Humulin 70/30 if you are allergic to insulin or if you haveintolerance to a certain insulin isophane and insulin regular product history of humulin.
• Before using insulin, tell your doctor if you have any other medicalconditions or if you take other prescription or over-the-counter medications,including vitamins, minerals, and herbal supplements history of humulin.
• Before using Humulin 70/30, tell your doctor if you have kidney or liverdisease history of humulin. You may require a dosage adjustment or special monitoring during treatment history of humulin.
• Most insulins can be used during pregnancy and breast-feeding history of humulin. They arenot expected to be harmful to an unborn baby history of humulin. It is very important to controlblood sugar levels during pregnancy and breast-feeding and insulin is oftenchosen as the treatment history of humulin. Some types of insulin may be better than others foruse during pregnancy and breast-feeding history of humulin. Talk to your doctor about the use ofinsulin during pregnancy and breast-feeding history of humulin.


How should I use Humulin 70/30?
• Use Humulin 70/30 exactly as directed by your doctor history of humulin. If you do not understandthese instructions, ask your doctor, nurse, or pharmacist to explain them toyou history of humulin.
• If the insulin has been stored in the refrigerator, it can be warmedto room temperature before use history of humulin.
• Roll the container of insulin between your palms 10 times history of humulin. Then, if youare using a pen or prefilled syringe, turn it upside down so that the glassball moves from one end to the other history of humulin. Do this at least 10 times history of humulin. Repeat thisprocedure until the suspension appears uniformly white and cloudy history of humulin. Do not shakethe insulin vigorously history of humulin. Inject immediately history of humulin. Repeat this procedure before eachsubsequent injection history of humulin.
• Do not use the insulin if it is discolored, has particles in it, or looksdifferent from previous vials, cartridges, or prefilled syringes of Humulin70/30 history of humulin.
• Use only the approved delivery device(s) for cartridges or prefilledsyringes of insulin history of humulin.
• If you are mixing different types of insulins in the same syringe, followyour doctor's directions and always draw up the different insulins in the sameorder (usually the clear insulin first) history of humulin. Do not mix different insulins in thesame syringe unless specifically directed to do so by your doctor history of humulin.
• Rotate injection sites exactly as directed by your doctor history of humulin. Usually, youshould not inject within 1 inch of the same site within 1 month history of humulin.
• Never reuse a needle or syringe history of humulin. Dispose of all needles and syringesin an appropriate, puncture-resistant disposal container history of humulin.
• Do not change the insulin strength (e.g., U-100) or insulin type (e.g.,50/50 isophane-regular mixture, 70/30 isophane-regular mixture, etc.) unlessyour doctor recommends a change for you history of humulin.
• Do not change the brand of insulin isophane and insulin regular or syringethat you are using without first talking to your doctor or pharmacist history of humulin. Somebrands of insulin isophane and insulin regular and syringes are interchangeable,while others are not history of humulin.
• Follow any diet and exercise plan that you have developed with your doctoror nurse history of humulin. Changes in what you eat or how much you exercise can change the amountof insulin that you need to control your blood sugar levels history of humulin.
• Ask your doctor or nurse what to do if you are sick with a cold, flu,or fever history of humulin. These illnesses may change your insulin requirements history of humulin.
• Your healthcare provider may recommend regular monitoring of blood sugarlevels with blood or urine tests history of humulin.
• Wear some type of medical identification bracelet, necklace, or otheralert tag to inform others that you have diabetes and that you require insulinin the case of an emergency history of humulin.
• Proper foot care, eye care, dental care, and overall proper health careare important for people with diabetes history of humulin. Visit your doctor, dentist, eye doctor,and other heath care practitioners as recommended by your doctor history of humulin.
• Store unopened vials, pens, and cartridges of Humulin 70/30 in the refrigeratorbetween 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius), in the originalcarton history of humulin. Do not store Humulin 70/30 in the freezer and do not allow it to freeze history of humulin. Do not use Humulin 70/30 if it has been frozen history of humulin. Throw away any expired insulin history of humulin.
• Vials of Humulin 70/30 can be kept unrefrigerated for up to 28 days,but should not be exposed to excessive heat or sunlight history of humulin.
• Once punctured, the vial of insulin in use, whether stored in the refrigeratoror at room temperature, must be used within 28 days history of humulin. Throw away any unused insulin28 days after the vial is first punctured history of humulin.
• Insulin cartridges and pens in use, should be stored at room temperature(below 86 degrees Fahrenheit/30 degrees Celsius), but should not be exposedto excessive heat or sunlight history of humulin. Novolin 70/30 PenFill and Prefilled cartridgesand Humulin 70/30 cartridges in use can be kept unrefrigerated for one week history of humulin. Humulin 70/30 Pens and Novolin 70/30 Innolets in use can be kept unrefrigeratedfor 10 days history of humulin. Unrefrigerated cartridges, pens, and Innolets must be used withinthis time period or discarded history of humulin.


What happens if I miss a dose?
• Follow your doctor's directions if you miss a dose of insulin history of humulin. To preventmissed doses, be sure to always have enough insulin on hand, especially if youare going on vacation history of humulin.


What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected history of humulin.
• Symptoms of an insulin overdose reflect very low blood sugar levels andinclude headache, irregular heartbeat, increased heart rate or pulse, sweating,tremor, nausea, increased hunger, and anxiety history of humulin.


What should I avoid while using Humulin 70/30?
• Do not use alcohol without first talking to your doctor history of humulin. It lowers bloodsugar, and you may experience dangerously low blood sugar levels history of humulin.


What are the possible side effects of Humulin 70/30?
• Rarely, people have allergic reactions to insulin history of humulin. Seek emergency medicalattention if you experience an allergic reaction (difficulty breathing; closingof the throat; swelling of the lips, tongue, or face; or hives) history of humulin.
• The side effects of insulin therapy result mostly from blood sugar levelsthat are either too high or too low history of humulin. You should be familiar with the symptomsof both high and low blood sugar levels and know how to treat both conditions history of humulin. Also, be sure your family and close friends know how to help you in an emergency history of humulin.
• Low blood sugar may occur when too much insulin is used; when meals aremissed or delayed; if you exercise more than usual; during illness, especiallywith vomiting or diarrhea; if you take other medications; after drinking alcohol;and in other situations history of humulin.
• Hypoglycemia, or low blood sugar, has the following symptoms: shaking;nausea; headache; drowsiness; weakness; dizziness; fast heartbeat; sweating;pale, cool skin; anxiety; and difficulty concentrating history of humulin.
• Keep sugary candy, fruit juice, or glucose tablets on hand to treat episodesof low blood sugar history of humulin.
• Increased blood sugar may occur if not enough insulin is used, if youeat significantly more food than usual, if you exercise less than usual, ifyou take other medications, if you have a fever or other illness, and in othersituations history of humulin.
• Hyperglycemia, or high blood sugar, has the following symptoms: increasedthirst, increased hunger, and increased urination history of humulin.
• Monitor your blood sugar levels and ask your doctor how to adjust yourinsulin doses if your blood sugar levels are too high history of humulin.
• Side effects may also occur at the site of injection history of humulin. If the area becomesthickened, hard, or pitted, talk to your doctor before injecting at that siteagain history of humulin.
• Side effects other than those listed here may also occur history of humulin. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome history of humulin.


What other drugs will affect Humulin 70/30?
• Many drugs can interact with insulin or affect blood sugar levels history of humulin. Donot take any other prescription or over-the-counter medicines, including vitamins,minerals, and herbal products, without first talking to your doctor or pharmacistduring treatment with insulin history of humulin.


Where can I get more information?
• Your pharmacist has additional information about Humulin 70/30 writtenfor health professionals that you may read history of humulin.


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