bisoprolo fumarate and hydrochlorothiazide

What is the most important information I should know about hydrochlorothiazide?
• To reduce nighttime urination, take hydrochlorothiazide early in theday unless otherwise directed by your doctor bisoprolo fumarate and hydrochlorothiazide.
• Use caution when driving, operating machinery, or performing other hazardousactivities bisoprolo fumarate and hydrochlorothiazide. Hydrochlorothiazide may cause dizziness bisoprolo fumarate and hydrochlorothiazide. If you experience dizziness,avoid these activities bisoprolo fumarate and hydrochlorothiazide.

What is hydrochlorothiazide?
• Hydrochlorothiazide is a thiazide diuretic (water pill) bisoprolo fumarate and hydrochlorothiazide. It decreasesthe amount of fluid in your body by increasing the amount of salt and wateryou lose in your urine bisoprolo fumarate and hydrochlorothiazide.
• Hydrochlorothiazide is used to lower blood pressure and to decrease edema(swelling) bisoprolo fumarate and hydrochlorothiazide.
• Hydrochlorothiazide may also be used for purposes other than those listedin this medication guide bisoprolo fumarate and hydrochlorothiazide.

Who should not take hydrochlorothiazide?
• Do not take hydrochlorothiazide without first talking to your doctorif you have an allergy to sulfa-based drugs such as sulfa antibiotics bisoprolo fumarate and hydrochlorothiazide. You mayhave an allergic reaction to hydrochlorothiazide bisoprolo fumarate and hydrochlorothiazide.
• Before taking hydrochlorothiazide, tell your doctor if you have
· diabetes,
· gout,
· a collagen vascular disease such as systemic lupus erythematosus,
· pancreatitis,
· kidney disease,
· liver disease, or
· high levels of cholesterol or triglycerides (types of fat) in yourblood bisoprolo fumarate and hydrochlorothiazide.
• You may need a dosage adjustment or special monitoring during therapyif you have any of the conditions listed above bisoprolo fumarate and hydrochlorothiazide.
• Hydrochlorothiazide is in the FDA pregnancy category B bisoprolo fumarate and hydrochlorothiazide. This means thatit is not expected to harm an unborn baby bisoprolo fumarate and hydrochlorothiazide. Do not take hydrochlorothiazide withoutfirst talking to your doctor if you are pregnant bisoprolo fumarate and hydrochlorothiazide.
• Hydrochlorothiazide passes into breast milk and may harm a nursing infant bisoprolo fumarate and hydrochlorothiazide. Do not take hydrochlorothiazide without first talking to your doctor if youare breast-feeding a baby bisoprolo fumarate and hydrochlorothiazide.

How should I take hydrochlorothiazide?
• Take hydrochlorothiazide exactly as directed by your doctor bisoprolo fumarate and hydrochlorothiazide. If you donot understand these directions, ask your pharmacist, nurse, or doctor to explainthem to you bisoprolo fumarate and hydrochlorothiazide.
• Take each dose with a full glass of water bisoprolo fumarate and hydrochlorothiazide.
• To reduce nighttime urination, take hydrochlorothiazide early in theday unless otherwise directed by your doctor bisoprolo fumarate and hydrochlorothiazide.
• Do not stop taking hydrochlorothiazide suddenly even if you feel better bisoprolo fumarate and hydrochlorothiazide. Stopping suddenly could make your condition worse bisoprolo fumarate and hydrochlorothiazide.
• Store this medication at room temperature away from moisture and heat bisoprolo fumarate and hydrochlorothiazide.

What happens if I miss a dose?
• Take the missed dose as soon as you remember bisoprolo fumarate and hydrochlorothiazide. However, if it is almosttime for your next dose, skip the dose you missed and take only your next regularlyscheduled dose bisoprolo fumarate and hydrochlorothiazide. Do not take a double dose of this medication bisoprolo fumarate and hydrochlorothiazide.

What happens if I overdose?
• Seek emergency medical attention bisoprolo fumarate and hydrochlorothiazide.
• Symptoms of a hydrochlorothiazide overdose include increased urination,nausea, vomiting, diarrhea, fatigue, lethargy, and unconsciousness bisoprolo fumarate and hydrochlorothiazide.

What should I avoid while taking hydrochlorothiazide?
• Use caution when driving, operating machinery, or performing other hazardousactivities bisoprolo fumarate and hydrochlorothiazide. Hydrochlorothiazide may cause dizziness bisoprolo fumarate and hydrochlorothiazide. If you experience dizziness,avoid these activities bisoprolo fumarate and hydrochlorothiazide.
• Use alcohol cautiously bisoprolo fumarate and hydrochlorothiazide. Alcohol may increase the side effects of hydrochlorothiazide bisoprolo fumarate and hydrochlorothiazide.
• Avoid a diet high in salt bisoprolo fumarate and hydrochlorothiazide. Too much salt may cause your body to retainwater and may decrease the effects of hydrochlorothiazide bisoprolo fumarate and hydrochlorothiazide.
• Avoid prolonged exposure to sunlight bisoprolo fumarate and hydrochlorothiazide. Hydrochlorothiazide may increasethe sensitivity of your skin to sunlight bisoprolo fumarate and hydrochlorothiazide. Use a sunscreen and wear protectiveclothing when exposure to the sun is unavoidable bisoprolo fumarate and hydrochlorothiazide.
• Avoid becoming overheated in hot weather and during exercise bisoprolo fumarate and hydrochlorothiazide. It is easierto become dangerously dehydrated while taking hydrochlorothiazide bisoprolo fumarate and hydrochlorothiazide.

What are the possible side effects of hydrochlorothiazide?
• If you experience any of the following serious side effects, stop takinghydrochlorothiazide and seek emergency medical attention:
· an allergic reaction (difficulty breathing; closing of your throat;swelling of your lips, tongue, or face; or hives);
· unusual fatigue;
· abnormal bleeding or bruising;
· yellow skin or eyes;
· confusion;
· irregular heartbeats or a fluttering feeling in your chest; or
· little or no urine bisoprolo fumarate and hydrochlorothiazide.
• Other, less serious side effects are more likely to occur bisoprolo fumarate and hydrochlorothiazide. Continue totake hydrochlorothiazide and talk to your doctor if you experience
· dizziness, especially when you switch to sitting or standing from alying position;
· tingling or numbness in your arms, legs, hands, or feet;
· excessive urination;
· muscle weakness or cramps;
· increased hunger or thirst;
· nausea or decreased appetite;
· abdominal pain;
· sensitivity to sunlight; or
· impotence bisoprolo fumarate and hydrochlorothiazide.
• Side effects other than those listed here may also occur bisoprolo fumarate and hydrochlorothiazide. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome bisoprolo fumarate and hydrochlorothiazide.

What other drugs will affect hydrochlorothiazide?
• Before taking hydrochlorothiazide tell your doctor if you are takingany of the following medications:
· lithium (Lithobid, Eskalith, others);
· digoxin (Lanoxin, Lanoxicaps);
· the cholesterol-lowering drugs cholestyramine (Questran) or colestipol(Colestid);
· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve), ketoprofen (Orudis, OrudisKT, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac(Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac(Clinoril), tolmetin (Tolectin), fenoprofen (Nalfon), ketorolac (Toradol), orflurbiprofen (Ansaid);
· a diabetes medication such as glipizide (Glucotrol), glyburide (Micronase,Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide(Orinase), and others; or
· a steroid medicine such as cortisone (Cortone), dexamethasone (Decadron,Hexadrol), hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone),prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others bisoprolo fumarate and hydrochlorothiazide.
• You may not be able to take hydrochlorothiazide, or you may require adosage adjustment or special monitoring during treatment if you are taking anyof the medications listed above bisoprolo fumarate and hydrochlorothiazide.
• Also, before taking hydrochlorothiazide, tell your doctor if you aretaking any other medicine to treat high blood pressure, water retention, heartproblems, prostate problems, or another condition bisoprolo fumarate and hydrochlorothiazide. Some medicines used to treatthese conditions may interact with hydrochlorothiazide and the effects on yourheart may be increased bisoprolo fumarate and hydrochlorothiazide.
• Hydrochlorothiazide may increase the effects of other drugs that causedrowsiness, including sedatives (used to treat insomnia), pain relievers, seizuremedicines, antidepressants, alcohol, antihistamines, anxiety medicines, andmuscle relaxants bisoprolo fumarate and hydrochlorothiazide. Tell your doctor about all medicines that you are taking,and do not take any medicine without first talking to your doctor bisoprolo fumarate and hydrochlorothiazide.
• Drugs other than those listed here may also interact with hydrochlorothiazideor affect your condition bisoprolo fumarate and hydrochlorothiazide. Talk to your doctor and pharmacist before taking anyprescription or over-the-counter medicines bisoprolo fumarate and hydrochlorothiazide.

Where can I get more information?
• Your pharmacist has additional information about hydrochlorothiazidewritten for health professionals that you may read bisoprolo fumarate and hydrochlorothiazide.

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