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losartan and hydrochlorothiazide (low SAR tan and hye droe klor oh THYE a zide)

What is the most important information I should know about Hyzaar?
• Do not take Hyzaar if you are pregnant or planning a pregnancy hyzaar product manager. Whenused during the second and third trimesters of pregnancy, losartan can causeinjury and even death to the developing fetus hyzaar product manager. Notify your doctor immediatelyif you think you might be pregnant hyzaar product manager.
• Use caution when driving, operating machinery, or performing other hazardousactivities hyzaar product manager. Hyzaar may cause dizziness or drowsiness hyzaar product manager. If you experience dizzinessor drowsiness, avoid these activities hyzaar product manager. Also use caution when rising from a sittingor lying position hyzaar product manager.
• Use alcohol cautiously hyzaar product manager. Alcohol may further lower blood pressure andincrease drowsiness and dizziness while you are taking Hyzaar hyzaar product manager.


What is Hyzaar?
• Losartan is in a class of drugs called angiotensin II receptor antagonists hyzaar product manager.
• Hydrochlorothiazide is a thiazide diuretic (water pill) hyzaar product manager. It increasesthe amount of water and salt you lose in your urine hyzaar product manager. Hydrochlorothiazide isused to lower blood pressure and to decrease edema (swelling) hyzaar product manager.
• Hyzaar is used to reduce hypertension (high blood pressure) hyzaar product manager.
• Hyzaar may also be used for purposes other than those listed in thismedication guide hyzaar product manager.


Who should not take Hyzaar?
• Do not take Hyzaar without first talking to your doctor if you have anallergy to sulfa-based drugs such as sulfa antibiotics hyzaar product manager. You may have an allergicreaction to hydrochlorothiazide hyzaar product manager.
• Before taking Hyzaar, tell your doctor if you
· have diabetes;
· have gout;
· have a collagen vascular disease such as systemic lupus erythematosus;
· have pancreatitis;
· have kidney disease;
· have liver disease;
· have any type of heart disease or have had a stroke;
· are on a salt-restricted diet or have high levels of potassium in yourblood; or
· are taking potassium supplements (e.g., K-Dur, Klor-Con, others), ora potassium-sparing diuretic such as amiloride (Midamor), triamterene (Dyrenium,Dyazide, Maxzide), or spironolactone (Aldactone) hyzaar product manager.
• You may not be able to take Hyzaar, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove hyzaar product manager.
• Hyzaar is in the FDA pregnancy category D hyzaar product manager. This means that it is knownto harm an unborn baby hyzaar product manager. When used during the second and third trimesters ofpregnancy, losartan can cause injury and even death of the developing fetus hyzaar product manager. Do not take this medication if you are pregnant hyzaar product manager.
• It is not known whether this drug passes into breast milk hyzaar product manager. Do not takeHyzaar without first talking to your doctor if you are breast-feeding a baby hyzaar product manager.


How should I take Hyzaar?
• Take Hyzaar exactly as directed by your doctor hyzaar product manager. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain them to you hyzaar product manager.
• Take each dose with a full glass (8 ounces) of water hyzaar product manager.
• You can take Hyzaar with or without food hyzaar product manager.
• Do not stop taking this medication without first talking to your doctor hyzaar product manager. If you stop taking this medication, your condition could become worse hyzaar product manager.
• Call your doctor before taking any more doses if you develop severe dizzinessor fainting hyzaar product manager.
• Store Hyzaar at room temperature away from moisture and heat hyzaar product manager.


What happens if I miss a dose?
• Take the missed dose as soon as you remember hyzaar product manager. However, if it is almosttime for your next dose, skip the missed dose and take only your next regularlyscheduled dose hyzaar product manager. Do not take a double dose of this medication hyzaar product manager.


What happens if I overdose?
• Seek emergency medical attention hyzaar product manager.
• Symptoms of a Hyzaar overdose are not well known but may include dizziness,weakness, fainting, and fatigue hyzaar product manager.


What should I avoid while taking Hyzaar?
• Use caution when driving, operating machinery, or performing other hazardousactivities hyzaar product manager. Hyzaar may cause dizziness or drowsiness hyzaar product manager. If you experience dizzinessor drowsiness, avoid these activities hyzaar product manager. Also use caution when rising from a sittingor lying position hyzaar product manager.
• Use alcohol cautiously hyzaar product manager. Alcohol may further lower blood pressure andincrease drowsiness and dizziness while you are taking Hyzaar hyzaar product manager.
• Avoid a diet high in salt hyzaar product manager. Too much salt may cause your body to retainwater and may decrease the effects of hydrochlorothiazide hyzaar product manager.
• Do not use salt substitutes or take potassium supplements without firsttalking to your doctor hyzaar product manager. Losartan can affect potassium levels in your body hyzaar product manager.
• Avoid prolonged exposure to sunlight hyzaar product manager. Hyzaar may increase the sensitivityof your skin to sunlight hyzaar product manager. Use a sunscreen and wear protective clothing whenexposure to the sun is unavoidable hyzaar product manager.
• Avoid becoming overheated in hot weather hyzaar product manager. It is easy to become dangerouslydehydrated while taking hydrochlorothiazide hyzaar product manager.


What are the possible side effects of Hyzaar?
• If you experience any of the following serious side effects, stop takingHyzaar and call your doctor immediately or seek emergency medical treatment hyzaar product manager.
· an allergic reaction (difficulty breathing; closing of your throat;swelling of your lips, tongue, or face; or hives);
· little or no urine;
· unusual fatigue, abnormal bleeding or bruising;
· yellow skin or eyes, confusion; or
· fainting hyzaar product manager.
• Other, less serious side effects may be more likely to occur hyzaar product manager. Continueto take Hyzaar and talk to your doctor if you experience
· diarrhea or upset stomach;
· muscle pain or cramps;
· dizziness;
· insomnia;
· congestion or cough;
· tingling or numbness in your arms, legs, hands, or feet;
· excessive urination;
· muscle weakness or cramps;
· increased hunger or thirst;
· nausea or decreased appetite; or
· sensitivity to sunlight hyzaar product manager.
• Side effects other than those listed here may also occur hyzaar product manager. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome hyzaar product manager.


What other drugs will affect Hyzaar?
• Before taking Hyzaar, tell your doctor if you are taking
· a potassium supplement such as K-Dur, Klor-Con, and others;
· a potassium-sparing diuretic (water pill) such as amiloride (Midamor),spironolactone (Aldactone), or triamterene (Dyrenium, Dyazide, Maxzide);
· a barbiturate such as phenobarbital (Luminal, Solfoton), pentobarbital(Nembutal), secobarbital (Seconal), mephobarbital (Mebaral), and others;
· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,Advil, Nuprin), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Cataflam,Voltaren), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro),naproxen (Naprosyn, Anaprox, Aleve), and others;
· an oral diabetes medication such as glipizide (Glucotrol), glyburide(Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase),or tolbutamide (Orinase);
· cholestyramine (Questran) or colestipol (Colestid);
· lithium (Lithobid, Eskalith, others); or
· digoxin (Lanoxin) hyzaar product manager.
• You may require a dosage adjustment or special monitoring during treatmentif you are taking any of the medicines listed above hyzaar product manager.
• Drugs other than those listed here may also interact with Hyzaar or affectyour condition hyzaar product manager. Talk to your doctor and pharmacist before taking any prescriptionor over-the-counter medicines hyzaar product manager.


Where can I get more information?
• Your pharmacist has additional information about Hyzaar written for healthprofessionals that you may read hyzaar product manager.


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